1=248442345BDS6Fig1BDCC2SRCRCSRCBD7RCBDSRCBDRCBDSRC8BDCC2SRCRCSRCBD9RCBDSRCBDRCBDSRC10BDCC2SRCRCSRCBD11RCBDSRCBDRCBDSRC12BDCC2SRCSRC13SSSSS0.13SFin fig1SSRC14Fig2BDCC2SxHBDxHBDSxHBD15xHBDSxHBDxHBDSxHBD16xHBDSxHBDxHBDSxHBD17xHBDSxHBDxHBDSxHBD18xHBDSxHBDxHBDSxHBD19xHBDSxHBDxHBDSxHBD20xHBDSxHBDxHBDSxHBD21xHBDSxHBDxHBDSoHBD22xHBDSxHBDxHBDSxHBD23xHBDSxHBDxHBDSxHBD24xHBDSxHBDxHBDSxHBD25xHBDSxHBDxHBD0.24SoHBD26xHBDSxHBDxHBDSxHBD27xHBDSxHBDxHBDSxHBD28BDoHSoHSoHSoH29SSSSS0.30SFin fig2SSRC30Fig3BDCC1SRCRCSRCBD31RCBDSRCBDRCBDSCC232BDCC1SRCRCSRCBD33RCBDSRCBDRCBDSCC234BDCC1SRCRCSRCBD35RCBDSRCBDRCBDSCC236BDCC1SRCRCSRCBD37RCBDS0.36SFTFTFTFTABDFTABDFT3338Fig3BDCC1SRCRCSRCBD39RCBDSRCBDRCBDSCC240BDCC1SRCRCSRCBD41RCBDSRCBDRCBDSCC242BDCC1SRCRCSRCBD43RCBDSRCBDRCBDSCC244BDCC1SRCRCSRCBD45RCBDSRCBD0.43RCBDFin fig3S46Fig4SoHBDoHBDSoHBDoHBD47SoHBDoHBDSoHBDoHBD48SoHBDoHSBDoHSoH49SSSSSSSCC2500.48BDSRCRCSRCBD51RCBDSRCBDRCBDSRC52BDCC2SRCRCSRC53SSSSS0.51SFin fig4BDSSCC254Fig2BDCC2SxHBDxHBDSxHBD55xHBDSxHBDxHBDSxHBD56xHBDSxHBDxHBDSxHBD57xHBDSxHBDxHBDSxHBD58xHBDSxHBDxHBDSxHBD59xHBDSxHBDxHBDSxHBD60xHBDSxHBDxHBDSxHBD61xHBDSxHBDxHBDSoHBD62xHBDSxHBDxHBDSxHBD63xHBDSxHBDxHBDSxHBD64xHBDSxHBDxHBDSxHBD65xHBDSxHBDxHBDSoHBD66xHBDSxHBDxHBDSxHBD67xHBDSxHBDxHBDSxHBD68BDoHSoHSoHSoH69SSSSS1.07SFin fig2SSRC70Fig3BDCC1SRCRCSRCBD71RCBDSRCBDRCBDSCC272BDCC1SRCRCSRCBD73RCBDSRCBDRCBDSCC274BDCC1SRCRCSRCBD75RCBDSRCBDRCBDSCC276BDCC1SRCRCSRCBD77RCBDS1.14SSSFig3SSCC278Fig3BDCC1SRCRCSRCBD79RCBDSRCBDRCBDSCC280BDCC1SRCRCSRCBD81RCBDSRCBDRCBDSCC282BDCC1SRCRCSRCBD83RCBDSRCBDRCBDSCC284BDCC1SRCRCSRCBD85RCBDSRCBD1.22RCBDFin fig3S86Fig4BSoHBDoHBDSoHBDoHBD87SoHBDoHBDSoHBDoHBD88SoHBDoHSBDoHSoH89SSSSSFTFTFT1.26FTFT90BDCC2SRCRCBDSRCBD91RCBDSRCBDRCBDSRC92BDCC2SRCRCBDSRCBD93RCBDSRCBDRCBDSRC94BDCC2SRCRCBDSRCBD95RCBDSRCBDRCBDSRC96BDCC2SRC1.33SRCS97SSSSSFin fig4BSSSCC198Fig5BDCC2SRCRCBDSRCBD99RCBDSRCBDRCBDSRCBD100RCBDSRCBDRCBDSRCBD101RCBDSRCBDRCBDSCC2102BDCC2SRCRCBDSRCBD103RCBDSRCBDRCBDSRCBD104RCBDSRCBD1.41SRCS105ABDFTSSABDFTSSABDFTSS1.42ABDFTSFin fig5SBDSBDS106Fig3BDCC1SRCRCSRCBD107RCBDSRCBDRCBDSCC2108BDCC1SRCRCSRCBD109RCBDSRCBDRCBDSCC2110BDCC1SRCRCSRCBD111RCBDSRCBDRCBDSCC2112BDCC1SRCRCSRCBD113RCBDCC21.50FTFTFTFTFTBDFTBDFT333114Fig3BDCC1SRCRCSRCBD115RCBDSRCBDRCBDSCC2116BDCC1SRCRCSRCBD117RCBDSRCBDRCBDSCC2118BDCC1SRCRCSRCBD119RCBDSRCBDRCBDSCC2120BDCC1SRCRCSRCBD121RCBDSRCBD1.57RCBDFin fig3S122Fig4BSoHBDoHBDSoHBDoHBD123SoHBDoHBDSoHBDoHBD124SoHBDoHSBDoHSoH125S1262.02SCC2FTcaBDSFTcaBDFTScaBD127FTcaBDSFTcaBDSFTcaBDFTcaBD128FTScaBDFTcaBDSFTcaBDFTScaBD129FTcaBDSFTcaBDSSFTcaBDFTcaBD130FTScaCC2BDFTcaBDSFTcaBDFTScaBD131FTcaBDSFTcaBDSFTcaBDFTcaBD132FTScaBDFTcaBDSFTcaBDFTScaBD133FTcaBDSFTca2.09S134BDCC2SRCRCBDSRCBD135RCBDSRCBDRCBDSRC136BDCC2SRCRCBDSRCBD137RCBDSRCBDRCBDSCC1138BDCC2SRCRCBDSRCBD139RCBDSRCBDRCBDSRC140BDCC2SRCRCBDSRCBD141RCBDSRCBDRC2.17BDSCC1142BDCC2SRCRCBDSRCBD143RCBDSRCBDRCBDSRC144BDCC2SRCRCBDSRCBD145RCBDSRCBDRCBDSCC1146BDCC2SRCRCBDSRCBD147RCBDSRCBDRCBDSRC148BDCC2SRCRCBDSRC2.23ABD149BDFTCC2ABDFTSSABDFTSSABDFTSSABDFT2.25SS150Fig5ABDCC2caSRCcaRCcaBDSRCcaBD151RCcaBDSRCcaBDRCcaBDSRCca152BDCC2caSRCcaRCcaBDSRCcaBD153RCcaBDSRCcaBDRCcaBDSCC1ca154BDCC2caSRCcaRCcaBDSRCcaBD155RCcaBDSRCcaBDRCcaBDSRCca156BDCC2caSRCcaRCcaBDSRCcaBD157SRCcaABDRCcaABDBDABDRCca2.32ABDBDFin fig5AABDRCcaABDBD158Fig5BBDCC2caSRCcaRCcaBDSRCcaBD159RCcaBDSRCcaBDRCcaBDSRCca160BDCC2caSRCcaRCcaBDSRCcaBD161RCcaBDSRCcaBDRCcaBDSCC1ca162BDCC2caSRCcaRCcaBDSRCcaBD163RCcaBDSRCcaBDRCcaBDSRCca164BDCC2caSRCcaRCcaBDSRCcaBD165RCcaBDSSBDFTS2.40SFTSABDSABDS166Fig5BBDCC2caSRCcaRCcaBDSRCcaBD167RCcaBDSRCcaBDRCcaBDSRCca168BDCC2caSRCcaRCcaBDSRCcaBD169RCcaBDSRCcaBDRCcaBDSCC1ca170BDCC2caSRCcaRCcaBDSRCcaBD171RCcaBDSRCcaBDRCcaBDSRCca172BDCC2caSRCcaRCcaBDSRCcaBD1732.47SSBDFTSSS2.40SBDFTCC2174Fig5BBDCC1caSRCcaRCcaBDSRCcaBD175RCcaBDSRCcaBDRCcaBDSRCca176BDCC2caSRCcaRCcaBDSRCcaBD177RCcaBDSRCcaBDRCcaBDSCC1ca178BDCC2caSRCcaRCcaBDSRCcaBD179RCcaBDSRCcaBDRCcaBDSRCca180BDCC2caSRCcaRCcaBDRCcaBD1812.55SSSSSSSS182BDCC2tatatatatata183tatatatatatatata184tatatatatata185186187188189190191192193